Notes ("notes") Between M.a.robinson Charitable Remainder Trust

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EXHIBIT 10.1


SECOND AMENDMENT TO THE MARCH 22, 1999 AND AUGUST 17, 1999 PROMISSORY
NOTES ("NOTES") BETWEEN M.A. ROBINSON CHARITABLE REMAINDER TRUST
("TRUST"), AND MARIUS A. ROBINSON (COLLECTIVELY, "ROBINSON") AND VYREX
CORPORATION ("THE COMPANY")


RECITALS


WHEREAS , The Company entered into promissory notes with Robinson dated March 22, 1999 and August 17, 1999.

WHEREAS , Robinson agreed on February 29, 2000 to extend the notes for one year for specific considerations.

WHEREAS , Robinson is willing, for the best interest of The Company, to extend both the March 22, 1999 and the August 17, 1999 notes to March 22, 2002.

NOW THEREFORE , in consideration for a s ...